At The Surgeon’s Spa – Beachwood and The Surgeon’s Spa – Westlake, platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and biofillers allow us to harness your body’s own regenerative potential to support smoother, healthier-looking skin. These treatments use components from your own blood—such as platelets, fibrin, and growth factors—to stimulate repair, collagen production, and rejuvenation from within.
PRP and PRF have long been used in medical fields such as orthopedics and wound care. Their ability to enhance tissue healing and regeneration has made them increasingly valuable tools in aesthetic medicine as well.
Your treatment begins with a simple blood draw, similar to what you might experience for routine lab work. The small blood sample is then placed into a centrifuge, which spins at high speed to separate it into different layers.
From this process, we can isolate:
When injected into targeted areas, these platelet-rich preparations release growth factors that:
Unlike traditional fillers, which primarily add volume directly, PRP and PRF are primarily aimed at stimulating your own tissue for gradual, natural-looking improvement.
While both PRP and PRF come from your own blood and contain platelets and growth factors, they differ in composition and behavior:
The choice between PRP and PRF—or a combination—depends on your goals, the treatment area, and the specific protocol recommended by your provider.
“Biofiller” refers to injectable treatments that use your own blood-derived components to create a gel-like material with regenerative properties. Because the term is sometimes used loosely online, it’s important to understand how it is defined at The Surgeon’s Spa.
Under Dr. Goldman’s guidance, we use the term biofiller to describe a gel created from:
Albumin: A protein found in the blood’s plasma (often collected as platelet-poor plasma, or PPP). When gently heated under controlled conditions, albumin forms a soft, semi-solid gel.
PRF (or PRP): Mixed with the albumin gel to provide a rich source of growth factors and regenerative cells.
The resulting biofiller gel can be injected similarly to traditional fillers, but its primary goal is bio-stimulation rather than immediate large-volume augmentation. As growth factors are slowly released from the gel matrix, they can support improvements in:
Because the response builds gradually, biofiller is often performed as a series of treatments, typically spaced over weeks to months, and can be combined with other therapies like conventional fillers, topical retinoids, lasers, or surgery.
Traditional fillers such as hyaluronic acid gels are designed to:
Biofillers, in contrast:
For many patients, the most effective strategy is not “either/or” but thoughtfully combining traditional fillers with bio-stimulating techniques to address both structure and skin quality.
PRP, PRF, and biofillers can be used in a variety of ways within a comprehensive aesthetic plan. Examples include:
PRP:
PRF and Biofiller:
Your provider will help determine which combination of regenerative injections best matches your goals and how they may fit into a broader program including fillers, lasers, or surgery.
Neither approach is universally “better.” Traditional fillers are excellent for restoring shape and volume quickly, while biofillers focus more on improving the skin itself over time. Many patients benefit from a combination, depending on their concerns and anatomy.
Some patients notice early improvements in skin glow or texture, but the most meaningful changes typically develop gradually over weeks to months as collagen production increases.
Regenerative protocols often involve a series of treatments, particularly for biofillers or hair restoration. Your provider will recommend a schedule based on your starting point and goals.
Ideal candidates are typically those who want to enhance skin quality or support hair growth using their own biologic materials, either alone or in combination with other treatments. A consultation is essential to determine which option, or combination, fits best with your overall plan.
Our advanced practice providers at The Surgeon’s Spa – Beachwood and The Surgeon’s Spa – Westlake have extensive experience with both traditional fillers and bio-stimulating treatments such as PRP, PRF, and biofillers. With the guidance of Dr. Goldman’s expertise in wound healing and facial rejuvenation, we can help you decide how regenerative injectables might enhance your overall aesthetic strategy.
